IsrM small RNA
From Wikipedia, the free encyclopedia
| IsrM sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of IsrM small RNA | |
| Identifiers | |
| Rfam | RF02763 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0009405 ,GO:0040033 |
| SO | SO:0000370 |
| PDB structures | PDBe |
The IsrM RNA is a small non-coding RNA discovered in Salmonella enterica pathogenicity island, which is not found in E. coli.[1] It is important for invasion of epithelial cells, intracellular replication inside macrophages, virulence and colonisation in mice. It targets the SopA and HilE mRNAs, virulence factors essential for bacterial invasion. It is a first pathogenicity island-encoded sRNA shown to be directly involved in Salmonella pathogenesis.[2]
