Isyana began her career as a journalist in 2003, when she was hired as a reporter for Trans TV.[1][5] About a year later, she moved to TV7, now known as Trans7, where she worked as both a reporter and a news presenter.[1] Then, in 2007, she was hired by RCTI as a presenter and producer of the Seputar Indonesia.[1][2] In 2013, she left RCTI to freelance, contributing to Metro TV, Sindo TV (now iNews), Kompas TV, Fox Sports Asia, and others.[3][5]
In her time as a reporter and presenter, she covered various events including the Aceh tsunami, the 2005 Bali bombings, and the 2008 United States presidential election.[1][3] She was also assigned to cover the executive branch during the presidency of Susilo Bambang Yudhoyono.[3] Past interviewees include U.S. President George W. Bush, Secretary of State Hillary Clinton, and sports figures Pep Guardiola, Cesc Fàbregas, Robert Pires, and Javier Zanetti.[6]
In 2014, Isyana joined other young people, including Grace Natalie and Raja Juli Antoni, to found the Indonesian Solidarity Party (PSI).[7][8][9] The following year, she formally ended her journalism career and began pursuing politics as a chair of the PSI's Central Leadership Council.[5][10] She cited as inspiration her grandmother Gedong Bagus Oka, a Hindu reformer who once served in the People's Consultative Assembly.[5]
In the 2019 Indonesian general election, Isyana joined the campaign team for the incumbent president, Joko Widodo.[11] As a PSI representative, she also ran for a seat in the House of Representatives for the Banten III district, receiving 48,819 personal votes.[3][12] However, her party did not reach the 4 percent threshold necessary to enter parliament.[3] She ran again in the same district in 2024, earning 78,140 votes, but her party again was unable to enter parliament.[13]
In October 2024, Isyana was named deputy minister of population and family development in new president Prabowo Subianto's Red White Cabinet.[14] In this role, she also serves as deputy head of the National Population and Family Planning Board.[14]
