Itruvone

Experimental drug From Wikipedia, the free encyclopedia

Itruvone (INNTooltip International Nonproprietary Name; developmental code name PH10), also known as pregn-4-en-20-yn-3-one, is a vomeropherine which is under development by VistaGen Therapeutics as a nasal spray for the treatment of major depressive disorder.[1][2][3][4][5][6]

Other namesPH10; PH10A; PH10 NS; Pregn-4-en-20-yn-3-one
Routes of
administrationIntranasal (spray)
Drug classVomeropherine
CAS Number
Quick facts Clinical data, Other names ...
Itruvone
Clinical data
Other namesPH10; PH10A; PH10 NS; Pregn-4-en-20-yn-3-one
Routes of
administration		Intranasal (spray)
Drug classVomeropherine
Identifiers
  • (8S,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC21H28O
Molar mass296.454 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C#C)CCC4=CC(=O)CC[C@]34C
  • InChI=1S/C21H28O/c1-4-14-6-8-18-17-7-5-15-13-16(22)9-11-21(15,3)19(17)10-12-20(14,18)2/h1,13-14,17-19H,5-12H2,2-3H3/t14-,17-,18-,19-,20+,21-/m0/s1
  • Key:CHOUAXDNNAVGHR-NWSAAYAGSA-N
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