JTC-801

JTC-801 is an opioid analgesic drug used in scientific research.^[1][2]

Other namesJTC-801

CAS Number

• 244218-51-7 ^Y

PubChem CID

• 5311340

IUPHAR/BPS

• 1692

Quick facts Clinical data, Other names ...

JTC-801

Clinical data
Other names	JTC-801
Identifiers
IUPAC name N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide
CAS Number	244218-51-7 Y
PubChem CID	5311340
IUPHAR/BPS	1692
ChemSpider	4470841 N
UNII	7I21WLZ2FP
CompTox Dashboard (EPA)	DTXSID301158085
Chemical and physical data
Formula	C26H25N3O2
Molar mass	411.505 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(c1ccccc1COc2ccc(cc2)CC)Nc3ccc4nc(cc(c4c3)N)C
InChI InChI=1S/C26H25N3O2/c1-3-18-8-11-21(12-9-18)31-16-19-6-4-5-7-22(19)26(30)29-20-10-13-25-23(15-20)24(27)14-17(2)28-25/h4-15H,3,16H2,1-2H3,(H2,27,28)(H,29,30) N Key:VTGBZWHPJFMTKS-UHFFFAOYSA-N N
NY (what is this?)  (verify)

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JTC-801 is a selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor.^[3] This was the fourth opioid receptor to be discovered and is still the least understood. The nociceptin receptor has complex effects which are involved in many processes involved in pain and inflammation responses, and activation of this receptor can either increase or reduce pain depending on dose.^[4] Drugs acting at the nociceptin receptor may influence the effects of traditional analgesics such as NSAIDs,^[5] μ-opioid agonists,^[6] and cannabinoids.^[7]

JTC-801 is an orally active drug that blocks the nociceptin receptor and produces analgesic effects in a variety of animal studies, and is particularly useful for neuropathic pain and allodynia associated with nerve injury.^[8][9][10]