JXL082

JXL082
Clinical data
Other names	JXL-082
Drug class	Mitochondrial pyruvate carrier (MPC) inhibitor
ATC code	None;
Identifiers
	IUPAC name ethyl (E)-3-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridin-3-yl]-2-cyanoprop-2-enoate;
CAS Number	2260696-75-9;
PubChem CID	137384919;
ChemSpider	129515069;
ChEMBL	ChEMBL4746172;
Chemical and physical data
Formula	C22H15F6N3O2
Molar mass	467.371 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC(=O)/C(=C/C1=CN(C2=C1C=CC=N2)CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)/C#N;
	InChI InChI=1S/C22H15F6N3O2/c1-2-33-20(32)14(10-29)8-15-12-31(19-18(15)4-3-5-30-19)11-13-6-16(21(23,24)25)9-17(7-13)22(26,27)28/h3-9,12H,2,11H2,1H3/b14-8+; Key:AIPLDVOUZVHAOG-RIYZIHGNSA-N;

JXL082, or JXL-082, is a drug acting as a mitochondrial pyruvate carrier (MPC) inhibitor which was synthesized towards the aim of developing a treatment for hair loss.^[1]^[2] It is related to other drugs in the same series such as PP405, JXL069, and UK-5099 (JXL001).^[1]^[2] The drug is known to have been sold online in a grey market fashion for treatment of hair loss.^[2] It has been mistakenly believed to be PP405, but PP405 is said not to be JXL082.^[2] JXL082 was first described in the scientific literature by 2019.^[3]^[1]