Jacalin-like lectin domain
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| Jacalin-like lectin domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of helianthus tuberosus lectin complexed to man(1-2)man | |||||||||
| Identifiers | |||||||||
| Symbol | Jacalin | ||||||||
| Pfam | PF01419 | ||||||||
| InterPro | IPR001229 | ||||||||
| SCOP2 | 1jac / SCOPe / SUPFAM | ||||||||
| |||||||||
In molecular biology, the jacalin-like lectin domain is a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B-cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.
Database of jacalin like lectins and structure function relations.[1] Proteins containing this domain include:
- Jacalin, a tetrameric plant seed lectin and agglutinin from Artocarpus heterophyllus (jackfruit), which is specific for galactose.[2]
- Artocarpin, a tetrameric plant seed lectin from A. heterophyllus.[3]
- Lectin MPA, a tetrameric plant seed lectin and agglutinin from Maclura pomifera (Osage orange).[4]
- Heltuba lectin, a plant seed lectin and agglutinin from Helianthus tuberosus (Jerusalem artichoke).[5]
- Agglutinin from Calystegia sepium (Hedge bindweed).[6]
- Griffithsin, an anti-viral lectin from red algae (Griffithsia species).[7]