Axelrod became known in the American comics industry in 2022, when she launched her graphic novel Galaxy: The Prettiest Star in May of that same year, published by DC Comics. Due to good sales in one year the publisher ran out of stock, leading DC to launch a reprint in 2023.[2]
In May 2023, in commemoration of LGBT Pride Month, Axelrod published the character encyclopedia The DC Book of Pride: A Celebration of DC's LGBTQIA+ Characters, an encyclopedia focused on the various LGBT characters of the DC Universe, including characters such as Alan Scott, Batwoman and Aruna Shende.[3]
That same month, she launched the 6-issue miniseries Hawkgirl, starring the superheroine of the same name.[4] The series was drawn by Amancay Nahuelpan[5] and concluded in its sixth issue in February 2024.
In May 2025, it was announced that a sequel to Axelrod's novel Galaxy: The Prettiest Star titled Galaxy: As The World Falls Down would be made, with Axelrod writing and artist Rye Hickman illustrating.[6] The book is slated to release in May 2026.
In July of that same year, it was announced at San Diego Comic-Con that Axelrod and Nicole Maines would write a Justice League Unlimited story centering around Galaxy, Dreamer, Adam Strange, Star Sapphire, and Green Arrow as they venture to Naltor, the home planet of Dreamer's mother.[7][8][9]
Axelrod is also currently the host of the American podcast The Voice Of Free Planet X.[10]