He was served heir to his father on 10 November 1674.[1] He attended the Parliament of Scotland in 1678, 1681 and 1685. He became a Privy Councillor of Scotland in 1686. He was considerably in debt and sold or mortgaged his estates to his second son. In 1688, he was put under pressure for payment to one of his creditors, William Ross the younger of Kindeace, and while they were walking together between Balnagowan and the ferry of Inverbreakie, Lord Duffus killed William Ross by running him through with a sword. He then fled to England,[3] where he remained until his friends had arranged a remission for him from the Crown. His mother, Lady Mackenzie of Seaforth wrote to him to say that "Many a man has fallen in such ane accident worse than your circumstances was, yet has been at peace with God and all the world, and lived very happily for all that". His remission was not long delayed as on 16 March 1689 he was among those who subscribed to the act declaring the legality of the meeting of the Estates summoned by the Prince of Orange, and on 15 April 1690 he also took the oath of allegiance to the Prince as William III of England.[2][3]
In 1695, an Act was passed which gave him the privilege of having two yearly fairs and a weekly market at Duffus. He voted in favour of the Darien scheme in 1701, and was against an increase of the forces.[2]
James Sutherland, 2nd Lord Duffus died on 24 September 1705.[2]