Jean Lud Cadet

In 1992 Cadet moved to the National Institute on Drug Abuse (NIDA), where he serves as National Institutes of Health Chief of the Molecular Neuropsychiatry Research Branch.^[2][3] His early research considered the effects of drugs on human memory.^[4] He has shown that the molecular networks within the brain are impacted by the acute administration of addictive substances. In particular, Cadet has considered the cellular mechanisms that underpin addiction of psychostimulants.^[3] Cadet has looked at the influence of addictive substances on the expression of immediate early gene (IEGs), and shown that IEGs can be induced within minutes of activation.^[5]

He has studied self-administration of methamphetamine,^[6] and shown that in striatal dopaminergic systems it is accompanied with markers of toxicity.^[3] This indicates that dopamine activates neurodegenerative processes within the brain, via the upregulation of neurotrophic factors and downregulation of glutamatergic systems.

• Bolla, K. I.; Brown, K.; Eldreth, D.; Tate, K.; Cadet, J. L. (2002-11-12). "Dose-related neurocognitive effects of marijuana use". Neurology. 59 (9): 1337–1343. doi:10.1212/01.WNL.0000031422.66442.49. ISSN 0028-3878. PMID 12427880. S2CID 11525660.

• Bolla, K. I; Eldreth, D. A; London, E. D; Kiehl, K. A; Mouratidis, M; Contoreggi, C; Matochik, J. A; Kurian, V; Cadet, J. L; Kimes, A. S; Funderburk, F. R (2003-07-01). "Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task". NeuroImage. 19 (3): 1085–1094. doi:10.1016/S1053-8119(03)00113-7. ISSN 1053-8119. PMC 2767245. PMID 12880834.

• Cadet, Jean Lud; Brannock, Christie (1998-02-01). "Invited Review Free radicals and the pathobiology of brain dopamine systems". Neurochemistry International. 32 (2): 117–131. doi:10.1016/S0197-0186(97)00031-4. ISSN 0197-0186. PMID 9542724. S2CID 24866888.