Holmes made his professional debut at King George's Hall in Blackburn on 30 March 2019, winning a four-round contest against Naheem Chaudhry on points in a fight which saw him knock his opponent to the canvas during the first round.[3]
After a stop-start career that was hampered by two hand surgeries and a failed brain scan,[4] he won his first pro-title by claiming the vacant English super-featherweight championship with a fourth round stoppage success over Lewis Wood at Bowlers Exhibition Centre in Manchester on 16 November 2024.[5][6] Holmes vacated the title without making any defenses.[7]
He faced Alex Murphy at Co-op Live Arena in Manchester on 28 March 2026.[8] After he knocked his opponent to the canvas for a second time in the first round the referee stopped the contest and awarded Holmes the win via technical knockout.[9][10]