KAT8
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
K(lysine) acetyltransferase 8 (KAT8) is an enzyme that in humans is encoded by the KAT8 gene.[5][6]
Function
The MYST family of histone acetyltransferases, which includes KAT8, was named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin.[6]
KAT8 is also known as MOF, and in humans hMOF. Given its fundamental role in modulating higher-order chromatin structure, hMOF is involved in many of the steps of the DNA damage response.[7] The human hMOF gene encodes an enzyme that specifically acetylates histone H4 at lysine 16.[7][8] The depletion of hMOF greatly decreases DNA double-strand break repair by both non-homologous end joining and homologous recombination.[8] Thus MOF activity is critical for double-strand break repair.[8]
