KDM3A

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene.[5]

AliasesKDM3A, JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA, lysine demethylase 3A
End86,492,716 bp[1]
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KDM3A
Identifiers
AliasesKDM3A, JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA, lysine demethylase 3A
External IDsOMIM: 611512; MGI: 98847; HomoloGene: 10196; GeneCards: KDM3A; OMA:KDM3A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146688
NM_018433

NM_001038695
NM_173001
NM_001362200
NM_001362201

RefSeq (protein)

NP_001140160
NP_060903

NP_001033784
NP_766589
NP_001349129
NP_001349130

Location (UCSC)Chr 2: 86.44 – 86.49 MbChr 6: 71.57 – 71.61 Mb
PubMed search[3][4]
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Function

This gene encodes a zinc finger protein that contains a jumonji C (JmjC) domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. KDM3A catalyzes the demethylation of H3K9me1 and H3K9me2 residues. Its function is dependent on the presence of cofactors Fe(II) and α-Ketoglutarate.[6]

References

Further reading

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