KDM4C

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesKDM4C, GASC1, JHDM3C, JMJD2C, TDRD14C, bA146B14.1, lysine demethylase 4C
Quick facts Available structures, PDB ...
KDM4C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKDM4C, GASC1, JHDM3C, JMJD2C, TDRD14C, bA146B14.1, lysine demethylase 4C
External IDsOMIM: 605469; MGI: 1924054; HomoloGene: 41004; GeneCards: KDM4C; OMA:KDM4C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001172095
NM_144787
NM_001356561

RefSeq (protein)

NP_001165566
NP_659036
NP_001343490

Location (UCSC)Chr 9: 6.72 – 7.18 MbChr 4: 74.16 – 74.32 Mb
PubMed search[3][4]
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Function

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily. It functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.[7] A expressional decrease of KDM4C was found during cardiac differentation of murine embryonic stem cells.[8]

References

Further reading

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