DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KINgene.[5][6]
The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.[6]
Kannouche P, Angulo JF (1999). "Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells". J. Cell Sci. 112 (19): 3215–24. doi:10.1242/jcs.112.19.3215. PMID10504327.
Miccoli L, Biard DS, Créminon C, Angulo JF (2002). "Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication". Cancer Res. 62 (19): 5425–35. PMID12359749.
Biard DS, Miccoli L, Despras E, etal. (2004). "Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes". Mol. Cancer Res. 1 (7): 519–31. PMID12754299.
