KLK12

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.^[5][6][7]

AliasesKLK12, KLK-L5, KLKL5, kallikrein related peptidase 12

External IDsOMIM: 605539; MGI: 1916761; GeneCards: KLK12

Chr.Chromosome 19 (human)^[1]

End51,035,230 bp^[1]

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KLK12
Identifiers
Aliases	KLK12, KLK-L5, KLKL5, kallikrein related peptidase 12
External IDs	OMIM: 605539; MGI: 1916761; GeneCards: KLK12
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,029,092 bp[1] End 51,035,230 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.26 cM Start 43,418,321 bp[2] End 43,423,009 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium oral cavity cervix epithelium mucosa of pharynx body of tongue superior surface of tongue vagina minor salivary glands amniotic fluid Top expressed in esophagus lip embryo stomach skin of external ear genital tubercle skin of back aorta ascending aorta nucleus of brain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity serine-type peptidase activity peptidase activity serine-type endopeptidase activity Cellular component extracellular region extracellular space secretory granule Biological process proteolysis cornification Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 43849 69511 Ensembl ENSG00000186474 ENSMUSG00000044430 UniProt Q9UKR0 B2RVZ0 RefSeq (mRNA) NM_019598 NM_145894 NM_145895 NM_001370125 NM_001370126 NM_001370127 NM_001370128 NM_027097 RefSeq (protein) NP_062544 NP_665901 NP_665902 NP_001357054 NP_001357055 NP_001357056 NP_001357057 NP_081373 Location (UCSC) Chr 19: 51.03 – 51.04 Mb Chr 7: 43.42 – 43.42 Mb PubMed search [3] [4]
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.^[7]