KLK4

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesKLK4, AI2A1, ARM1, EMSP, EMSP1, KLK-L1, PRSS17, PSTS, kallikrein, kallikrein related peptidase 4

External IDsOMIM: 603767; MGI: 1861379; HomoloGene: 55856; GeneCards: KLK4; OMA:KLK4 - orthologs

Chr.Chromosome 19 (human)^[1]

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KLK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BDG, 2BDH, 2BDI, 4K1E, 4K8Y, 4KEL, 4KGA
Identifiers
Aliases	KLK4, AI2A1, ARM1, EMSP, EMSP1, KLK-L1, PRSS17, PSTS, kallikrein, kallikrein related peptidase 4
External IDs	OMIM: 603767; MGI: 1861379; HomoloGene: 55856; GeneCards: KLK4; OMA:KLK4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 50,906,351 bp[1] End 50,911,395 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.35 cM Start 43,530,584 bp[2] End 43,535,228 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prostate mucosa of transverse colon testicle skin of leg skin of abdomen gonad salivary gland minor salivary glands left lobe of thyroid gland canal of the cervix Top expressed in molar decidua thymus muscle rhombencephalon pituitary gland adipose tissue brown adipose tissue muscle tissue torso More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity protein binding hydrolase activity metal ion binding serine-type endopeptidase activity Cellular component extracellular region secretory granule Biological process proteolysis amelogenesis biomineral tissue development extracellular matrix disassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9622 56640 Ensembl ENSG00000167749 ENSMUSG00000006948 UniProt Q9Y5K2 Q9Z0M1 RefSeq (mRNA) NM_001302961 NM_004917 NM_019928 RefSeq (protein) NP_001289890 NP_004908 NP_064312 Location (UCSC) Chr 19: 50.91 – 50.91 Mb Chr 7: 43.53 – 43.54 Mb PubMed search [3] [4]
Wikidata
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Kallikreins are a subgroup of serine proteases having diverse physiological functions.^[8] Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins.^[9] Alternate splice variants for this gene have been described, but their biological validity has not been determined.^[10]