KLK8

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.^{[5][6][7][8][9]}

AliasesKLK8, HNP, NP, NRPN, PRSS19, TADG14, kallikrein related peptidase 8

External IDsOMIM: 605644; MGI: 1343327; GeneCards: KLK8

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 19 (human)^[1]

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KLK8
Identifiers
Aliases	KLK8, HNP, NP, NRPN, PRSS19, TADG14, kallikrein related peptidase 8
External IDs	OMIM: 605644; MGI: 1343327; GeneCards: KLK8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NPM
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.4.21.118 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 50,996,007 bp[1] End 51,002,711 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.26 cM Start 43,447,001 bp[2] End 43,453,250 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg testicle right uterine tube vagina human penis oral cavity minor salivary glands vulva gonad Top expressed in lip esophagus superior surface of tongue skin of external ear vas deferens embryo embryo epiblast skin of abdomen blood More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity protein binding hydrolase activity Cellular component cytoplasm extracellular region extracellular space serine protease inhibitor complex secretory granule Biological process synapse organization keratinocyte proliferation negative regulation of axon regeneration neuron projection morphogenesis cell death memory response to wounding negative regulation of myelination regulation of synapse organization proteolysis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 11202 259277 Ensembl ENSG00000129455 ENSMUSG00000064023 UniProt O60259 Q61955 RefSeq (mRNA) NM_001281431 NM_007196 NM_144505 NM_144506 NM_144507 NM_008940 NM_001324398 RefSeq (protein) NP_001268360 NP_009127 NP_653088 NP_653089 NP_653090 NP_001311327 NP_032966 Location (UCSC) Chr 19: 51 – 51 Mb Chr 7: 43.45 – 43.45 Mb PubMed search [3] [4]
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.^[9]