KMO (gene)

AliasesKMO, dJ317G22.1, kynurenine 3-monooxygenase (kynurenine 3-hydroxylase), kynurenine 3-monooxygenase

External IDsOMIM: 603538; MGI: 2138151; HomoloGene: 2729; GeneCards: KMO; OMA:KMO - orthologs

Chr.Chromosome 1 (human)^[1]

End241,595,642 bp^[1]

KMO
Identifiers
Aliases	KMO, dJ317G22.1, kynurenine 3-monooxygenase (kynurenine 3-hydroxylase), kynurenine 3-monooxygenase
External IDs	OMIM: 603538; MGI: 2138151; HomoloGene: 2729; GeneCards: KMO; OMA:KMO - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q43 Start 241,532,134 bp[1] End 241,595,642 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 175,447,947 bp[2] End 175,489,682 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver palpebral conjunctiva kidney tubule testicle glomerulus metanephric glomerulus placenta monocyte human kidney granulocyte Top expressed in left lobe of liver right kidney human kidney proximal tubule spleen mesenteric lymph nodes blood yolk sac lumbar subsegment of spinal cord bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function NAD(P)H oxidase H2O2-forming activity monooxygenase activity oxidoreductase activity kynurenine 3-monooxygenase activity flavin adenine dinucleotide binding FAD binding Cellular component integral component of membrane cytosol membrane mitochondrial outer membrane mitochondrion mitochondrial membranes extracellular space Biological process pyridine nucleotide biosynthetic process NAD biosynthetic process response to salt stress secondary metabolite biosynthetic process quinolinate biosynthetic process tryptophan catabolic process response to lipopolysaccharide cellular response to interleukin-1 L-kynurenine metabolic process positive regulation of neuron death positive regulation of glutamate secretion, neurotransmission NAD metabolic process kynurenine metabolic process 'de novo' NAD biosynthetic process from tryptophan anthranilate metabolic process ageing positive regulation of glutamate secretion kynurenic acid biosynthetic process cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8564 98256 Ensembl ENSG00000117009 ENSMUSG00000039783 UniProt O15229 Q91WN4 RefSeq (mRNA) NM_003679 NM_133809 RefSeq (protein) NP_003670 NP_598570 Location (UCSC) Chr 1: 241.53 – 241.6 Mb Chr 1: 175.45 – 175.49 Mb PubMed search [3] [4]
Wikidata
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Kynurenine 3-monooxygenase is an enzyme that in humans is encoded by the KMO gene.^[5][6]

Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine.[supplied by OMIM]^[6] This is the first step in the degradation of Kyneurinine to Quinolinic acid. This pathway is involved in the activation of cytokine mediated changes in behavior due to inflammatory stimuli such as infections.^[7] The KMO gene is upregulated in the lung parenchyma of smokers. ^[8]