Kahn Sagol Maccabi
Research and Innovation Center in Israel
From Wikipedia, the free encyclopedia
The Kahn-Sagol-Maccabi (KSM) for Research and Innovation (in Hebrew: מכון קאהן-סגול-מכבי למחקר ולחדשנות) is the Research and Innovation Center of Maccabi Healthcare Services.[1]
מכון קאהן-סגול-מכבי למחקר ולחדשנות (Hebrew) | |
| |
| Type | Medical research |
|---|---|
| Established | 2016 |
| Location | Israel |
| Website | www |
History
Founded in 2016 by Maccabi Health Services with the key support of Morris Kahn and Sami Sagaol, KSM promotes excellence in medical research.[2]
It wasa formerly headed by Prof. Varda Shalev and is currently headed by Dr. Tal Patalon.[3]
Activities and services
Medical studies
KSM Center strives to enhance healthcare systems through independent research and partnerships with international researchers,[4] academic institutions, pharmaceutical companies, start-ups and technology firms.[5][6]
Since its inception, the center has conducted hundreds of studies,[7] resulting in the development of tools for both patients and healthcare providers.[8] These studies have influenced medical policies in several countries, particularly during the COVID-19 pandemic.[9]
Notable studies conducted under KSM's auspices include:
- Studies on the coronavirus epidemic – During the COVID-19 pandemic, several international scientific studies based on the Maccabi databases were conducted by the center, Including studies on repeated infection in children,[10] repeated infection in adults,[11] natural vaccination,[12][9] reduction of transmission[13] the decline in the effect of the third vaccine[14] the effect of the vaccine on intra-domestic infection[15] and on patients with Coeliac disease.[16]
- Research on mpox – In 2023, a study on mpox based on KSM's analysis and database was published.[17]
- Research on Parvovirus B19 – In 2023, a study on a local outbreak of parvovirus was published.[18]
- Research on autism – In 2023, a study on late diagnosis of autism was published.[19]
- Research on cancer – In 2023, a study of the effects of palbociclib treatment on the lifespan of patients with breast cancer was published.[20]
Medical database
KSM's research activities are based on independent efforts, as well as the extensive medical knowledge and database of Maccabi Health Services.[21] This database, compiled over three decades and anonymized, encompasses digital records of 2.7 million insured individuals.[22]
In addition to its in-house research,[23] the Center offers global researchers access to conduct studies, analyses [30] and medical prediction,[24] based on this comprehensive database.[25]
KSM's innovation and big data deKSM's innovation and big data department uses databases and artificial intelligence technologies to support research activities, data analysis, and medical prediction.[26]
Biobank
The KSM Center has established the Tipa BioBank,[27] Israel's largest biobank[28] housing over a million genetic samples for research purposes.[29][8]
The purpose of this initiative is to develop tools for early disease detection through genetic[30] and biological studies.[31] A central feature of this effort is the creation of a repository of biological samples (e.g., blood, urine, etc.), enabling researchers to investigate how genetic profiles influence disease risk and treatment.[32]
Main publications
- Gazit, Sivan; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Stuart, Elizabeth A.; Patalon, Tal (2023). "Hybrid immunity against reinfection with SARS-CoV-2 following a previous SARS-CoV-2 infection and single dose of the BNT162b2 vaccine in children and adolescents: A target trial emulation". The Lancet Microbe. 4 (7): e495–e505. doi:10.1016/S2666-5247(23)00103-9. PMC 10101759. PMID 37062294.
- Shapira, Guy; Patalon, Tal; Gazit, Sivan; Shomron, Noam (2023). "Immunosuppression as a Hub for SARS-CoV-2 Mutational Drift". Viruses. 15 (4): 855. doi:10.3390/v15040855. PMC 10145566. PMID 37112835.
- Patalon, Tal; Saciuk, Yaki; Perez, Galit; Peretz, Asaf; Ben-Tov, Amir; Gazit, Sivan (2023). "Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents". The Journal of Pediatrics. 257. doi:10.1016/j.jpeds.2023.02.016. PMC 9981270. PMID 36870558.
- Gazit, Sivan; Shlezinger, Roei; Perez, Galit; Lotan, Roni; Peretz, Asaf; Ben-Tov, Amir; Herzel, Esma; Alapi, Hillel; Cohen, Dani; Muhsen, Khitam; Chodick, Gabriel; Patalon, Tal (2022). "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Naturally Acquired Immunity versus Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: A Retrospective Cohort Study". Clinical Infectious Diseases. 75 (1): e545–e551. doi:10.1093/cid/ciac262. PMC 9047157. PMID 35380632.
- Gazit, Sivan; Shlezinger, Roei; Perez, Galit; Lotan, Roni; Peretz, Asaf; Ben-Tov, Amir; Herzel, Esma; Alapi, Hillel; Cohen, Dani; Muhsen, Khitam; Chodick, Gabriel; Patalon, Tal (2022). "The Incidence of SARS-CoV-2 Reinfection in Persons with Naturally Acquired Immunity with and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine". Annals of Internal Medicine. 175 (5): 674–681. doi:10.7326/M21-4130. PMC 8855786. PMID 35157493.
- Ben-Tov, Amir; Lebwohl, Benjamin; Banon, Tamar; Chodick, Gabriel; Kariv, Revital; Assa, Amit; Gazit, Sivan; Patalon, Tal (2023). "BNT162b2 mRNA COVID-19 Vaccine Effectiveness in Patients with Coeliac Disease Autoimmunity: Real-World Data from Mass Vaccination Campaign". Viruses. 15 (9): 1968. doi:10.3390/v15091968. PMC 10534420. PMID 37766374.
- Lechtman, Niva; Shamir, Raanan; Cohen, Shlomi; Chodick, Gabriel; Kariv, Revital; Supino-Rosin, Lia; Weintraub, Yael; Yerushalmy-Feler, Anat; Ben Tov, Amir (2021). "Increased incidence of coeliac disease autoimmunity rate in Israel: A 9-year analysis of population-based data". Alimentary Pharmacology & Therapeutics. 53 (6): 696–703. doi:10.1111/apt.16282. PMID 33547687. S2CID 231946967.