Ketol-acid reductoisomerase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, ketol-acid reductoisomerase (EC 1.1.1.86) is an enzyme that catalyzes the chemical reaction
-Acetolactic_acid.svg)
-2,3-dihydroxy-3-methylbutanoic_acid.svg)
| ketol-acid reductoisomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Ketol-acid reductoisomerase tetramer, Alicyclobacillus acidocaldarius | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.86 | ||||||||
| CAS no. | 9075-02-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The two substrates of this enzyme are (R)-2,3-dihydroxy-3-methylbutanoic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are acetolactic acid, NADPH, and a proton.[1][2][3][4][5]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing). Other names in common use include dihydroxyisovalerate dehydrogenase (isomerizing), acetohydroxy acid isomeroreductase, ketol acid reductoisomerase, alpha-keto-beta-hydroxylacyl reductoisomerase, 2-hydroxy-3-keto acid reductoisomerase, acetohydroxy acid reductoisomerase, acetolactate reductoisomerase, dihydroxyisovalerate (isomerizing) dehydrogenase, isomeroreductase, and reductoisomerase. This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coa biosynthesis.
