He may have been a son of King Menkaure and was a son of his sister, Queen Khamerernebty II.[2] He was a grandson of Khafre and Khamerernebty I and great-grandson of Khufu, the king who built the Great Pyramid of Giza.[3][4]
He was a secretary and "sole companion of his father".[5]
He was the eldest son of his parents, but he was not Menkaure’s successor as he predeceased him.[6] Thus, Menkaure was succeeded by Shepseskaf.[7]
Khuenre is buried in Menkaure’s cemetery (MQ 1). He is depicted as a young boy standing in front of his seated mother on the south wall.[5]