L-2-hydroxycarboxylate dehydrogenase (NAD+)
Class of enzymes
From Wikipedia, the free encyclopedia
L-2-hydroxycarboxylate dehydrogenase (NAD+) (EC 1.1.1.337, (R)-sulfolactate:NAD+ oxidoreductase, L-sulfolactate dehydrogenase, (R)-sulfolactate dehydrogenase, L-2-hydroxyacid dehydrogenase (NAD+), ComC) is an enzyme with systematic name (2S)-2-hydroxycarboxylate:NAD+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- (2S)-2-hydroxycarboxylate + NAD+ 2-oxocarboxylate + NADH + H+
| L-2-hydroxycarboxylate dehydrogenase (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.337 | ||||||||
| CAS no. | 81210-65-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme from the archaeon Methanocaldococcus jannaschii uses as a substrate multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate.
