L-368,899

L-368,899
Clinical data
ATC code	None;
Identifiers
	IUPAC name (S)-2-amino-N-((1S,2S,4R)-7,7-dimethyl-1-((4-o-tolylpiperazin-1-ylsulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide;
CAS Number	148927-60-0 ;
PubChem CID	132857;
IUPHAR/BPS	2249;
ChemSpider	8048078;
UNII	ER33G946JT;
ChEMBL	ChEMBL1253853;
CompTox Dashboard (EPA)	DTXSID80933504 ;
Chemical and physical data
Formula	C26H42N4O5S2
Molar mass	554.77 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1(C)[C@@]2(CS(N3CCN(C4=CC=CC=C4C)CC3)(=O)=O)CC[C@@H]1C[C@@H]2NC([C@H](CCS(C)(=O)=O)N)=O;
	(verify)

L-368,899 is a drug used in scientific research which acts as a selective antagonist of the oxytocin receptor, with good selectivity over the related vasopressin receptors.^[1] Unlike related drugs such as the peripherally selective L-371,257, the oral bioavailabity is high and the brain penetration of L-368,899 is rapid, with selective accumulation in areas of the limbic system. This makes it a useful tool for investigating the centrally mediated roles of oxytocin, such as in social behaviour and pair bonding, and studies in primates have shown L-368,899 to reduce a number of behaviours such as food sharing, sexual activity and caring for infants, demonstrating the importance of oxytocinergic signalling in mediating these important social behaviours.^[2]^[3]