L-765,314

L-765,314 is a drug which acts as a potent and selective antagonist of the α₁-adrenergic receptor subtype α_1B.^[1] It has mainly been used to investigate the role of α_1B-adrenergic receptors in the regulation of blood pressure.^[2][3] The α_1B receptor is also thought to have an important role in the brain; however, L-765,314 does not cross the blood–brain barrier.^[4]

CAS Number

• 189349-50-6 ^Y

PubChem CID

• 6603904

IUPHAR/BPS

• 506

ChemSpider

• 5036212 ^N

Quick facts Identifiers, CAS Number ...

L-765,314

Identifiers
IUPAC name benzyl (2S)-4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-2-(tert-butylcarbamoyl)piperazine-1-carboxylate
CAS Number	189349-50-6 Y
PubChem CID	6603904
IUPHAR/BPS	506
ChemSpider	5036212 N
UNII	CR7JLF2GBM
ChEMBL	ChEMBL19476 N
CompTox Dashboard (EPA)	DTXSID901028767
Chemical and physical data
Formula	C27H34N6O5
Molar mass	522.606 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)(C)NC(=O)[C@@H]1CN(CCN1C(=O)OCc2ccccc2)c3nc4cc(c(cc4c(n3)N)OC)OC
InChI InChI=1S/C27H34N6O5/c1-27(2,3)31-24(34)20-15-32(11-12-33(20)26(35)38-16-17-9-7-6-8-10-17)25-29-19-14-22(37-5)21(36-4)13-18(19)23(28)30-25/h6-10,13-14,20H,11-12,15-16H2,1-5H3,(H,31,34)(H2,28,29,30)/t20-/m0/s1 N Key:CGWOIDCAGBKOQL-FQEVSTJZSA-N N
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