LIPH (gene)

AliasesLIPH, AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1, lipase H

External IDsOMIM: 607365; MGI: 2388029; HomoloGene: 71802; GeneCards: LIPH; OMA:LIPH - orthologs

Chr.Chromosome 3 (human)^[1]

End185,552,588 bp^[1]

LIPH
Identifiers
Aliases	LIPH, AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1, lipase H
External IDs	OMIM: 607365; MGI: 2388029; HomoloGene: 71802; GeneCards: LIPH; OMA:LIPH - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.2 Start 185,506,262 bp[1] End 185,552,588 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B1|16 12.95 cM Start 21,772,567 bp[2] End 21,814,413 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell rectum pancreatic ductal cell mucosa of transverse colon islet of Langerhans olfactory zone of nasal mucosa nasal epithelium epithelium of nasopharynx mucosa of ileum mucosa of sigmoid colon Top expressed in epithelium of stomach transitional epithelium of urinary bladder lobe of prostate duodenum vestibular membrane of cochlear duct otolith organ ileum utricle right lung lobe left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding carboxylic ester hydrolase activity hydrolase activity phospholipase activity lipase activity Cellular component extracellular region plasma membrane membrane extracellular space Biological process lipid catabolic process lipid metabolism phosphatidic acid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200879 239759 Ensembl ENSG00000163898 ENSMUSG00000044626 UniProt Q8WWY8 Q8CIV3 RefSeq (mRNA) NM_139248 NM_001083894 NM_001289581 NM_001289582 NM_153404 RefSeq (protein) NP_640341 NP_001077363 NP_001276510 NP_001276511 NP_700453 Location (UCSC) Chr 3: 185.51 – 185.55 Mb Chr 16: 21.77 – 21.81 Mb PubMed search [3] [4]
Wikidata
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Lipase member H is an enzyme that in humans is encoded by the LIPH gene.^[5][6][7]

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.^[7]