LOXL4

Lysyl oxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene.^[5][6]

AliasesLOXL4, LOXC, lysyl oxidase like 4

External IDsOMIM: 607318; MGI: 1914823; HomoloGene: 12977; GeneCards: LOXL4; OMA:LOXL4 - orthologs

Chr.Chromosome 10 (human)^[1]

End98,268,194 bp^[1]

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LOXL4
Identifiers
Aliases	LOXL4, LOXC, lysyl oxidase like 4
External IDs	OMIM: 607318; MGI: 1914823; HomoloGene: 12977; GeneCards: LOXL4; OMA:LOXL4 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 98,247,690 bp[1] End 98,268,194 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 42,582,421 bp[2] End 42,601,252 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia islet of Langerhans cartilage tissue tibialis anterior muscle pancreatic epithelial cell tendon of biceps brachii pancreatic ductal cell olfactory zone of nasal mucosa nasal epithelium stromal cell of endometrium Top expressed in membranous bone calvaria Dermatocranium maxilla mandible molar rib lumbar spinal ganglion ascending aorta skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function scavenger receptor activity oxidoreductase activity copper ion binding protein binding oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor metal ion binding protein-lysine 6-oxidase activity Cellular component extracellular region receptor complex extracellular exosome membrane extracellular space Biological process receptor-mediated endocytosis peptidyl-lysine oxidation collagen fibril organization vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84171 67573 Ensembl ENSG00000138131 ENSMUSG00000025185 UniProt Q96JB6 Q924C6 RefSeq (mRNA) NM_032211 NM_001164311 NM_053083 RefSeq (protein) NP_115587 NP_001157783 NP_444313 Location (UCSC) Chr 10: 98.25 – 98.27 Mb Chr 19: 42.58 – 42.6 Mb PubMed search [3] [4]
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This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.^[6]