LRRC24
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| LRRC24 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | LRRC24, LRRC14OS, leucine rich repeat containing 24 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 3605040; HomoloGene: 86785; GeneCards: LRRC24; OMA:LRRC24 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Leucine rich repeat containing 24 is a protein that, in humans, is encoded by the LRRC24 gene.[5] The protein is represented by the official symbol LRRC24, and is alternatively known as LRRC14OS.[6] The function of LRRC24 is currently unknown. It is a member of the leucine-rich repeat (LRR) superfamily of proteins.
In humans, LRRC24 is located on Chromosome 8 (8q24.3). The gene spans approximately 4.66 kb on the opposite strand.[5] LRRC24 is composed of five exons, and only a single gene isoform has been identified.[5]
Protein
General features
LRRC24 is a transmembrane protein of unknown function. Human LRRC24 consists of 513 amino acids including a 23 amino acid signal peptide.[5][7] The mature form of the protein has a molecular weight of 52.9 kDa.[8] The isoelectric point of the mature human protein is 7.98[9] The protein is largely composed of alpha helices.[10]
Domains
LRRC24 is a single-pass transmembrane protein. The protein consists of six leucine-rich repeats and an immunoglobulin-like domain.[5][11]
| Feature | Position(s) | Description |
|---|---|---|
| Signal Peptide | 1-23 | [12] |
| Domain | 24-50 | Leucine rich repeat N-terminal domain (LRRNT)[13][14] |
| Repeat | 51-72 | Leucine rich repeat 1 (LRR 1)[13][14] |
| Repeat | 75-96 | LRR 2[13][14] |
| Repeat | 99-120 | LRR 3[13][14] |
| Repeat | 123-144 | LRR 4[13][14] |
| Repeat | 147-168 | LRR 5[13][14] |
| Repeat | 171-192 | LRR 6[13][14] |
| Domain | 204-257 | Leucine rich repeat C-terminal domain (LRRCT)[13][14] |
| Domain | 259-364 | Immunoglobulin-like domain (Ig-like)[13][14] |
| Domain | 406-426 | Transmembrane domain (TMEM)[15] |
| Motif | 427-436 | Arginine-rich motif (ARM)[13] |
Localization
LRRC24 is a secreted protein as is evidenced by the presence of a signal peptide. The structure of the protein suggests that it localizes to the cell membrane.
Homology
LRRC24 is conserved in Euteleostomi with the exception of Aves.[5][18] Also, based on sequence homology analysis, distant orthologs of LRRC24 are also conserved in invertebrates of phyla Mollusca and Arthropoda.[5] No human paralogs of LRRC24 have been identified.
Expression
Microarray and in situ hybridization experiments suggest LRRC24 is primarily expressed within the brain.[20][21][22] Expression is observed to be especially high within the midbrain, neocortex, and tissues of the limbic system, including the hypothalamus and hippocampal formation.[20][22][23]