LRRK1

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene.^[5][6][7]

AliasesLRRK1, RIPK6, Roco1, leucine-rich repeat kinase 1, leucine rich repeat kinase 1, OSMD

External IDsOMIM: 610986; MGI: 2142227; HomoloGene: 23464; GeneCards: LRRK1; OMA:LRRK1 - orthologs

Chr.Chromosome 15 (human)^[1]

End101,078,257 bp^[1]

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LRRK1
Identifiers
Aliases	LRRK1, RIPK6, Roco1, leucine-rich repeat kinase 1, leucine rich repeat kinase 1, OSMD
External IDs	OMIM: 610986; MGI: 2142227; HomoloGene: 23464; GeneCards: LRRK1; OMA:LRRK1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.3 Start 100,919,327 bp[1] End 101,078,257 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 C Start 65,876,660 bp[2] End 66,038,098 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node appendix transverse colon spleen monocyte mucosa of transverse colon minor salivary glands skin of leg rectum stromal cell of endometrium Top expressed in right lung lobe transitional epithelium of urinary bladder left lung medullary collecting duct left lung lobe endothelial cell of lymphatic vessel conjunctival fornix mesenteric lymph nodes stroma of bone marrow epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity GTP binding protein binding ATP binding metal ion binding identical protein binding protein serine/threonine kinase activity signal transducer activity Cellular component mitochondrion cytoplasm cytosol Biological process positive regulation of canonical Wnt signaling pathway osteoclast development negative regulation of peptidyl-tyrosine phosphorylation positive regulation of intracellular signal transduction bone resorption phosphorylation positive regulation of peptidyl-tyrosine phosphorylation intracellular signal transduction protein phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79705 233328 Ensembl ENSG00000154237 ENSMUSG00000015133 UniProt Q38SD2 Q3UHC2 RefSeq (mRNA) NM_024652 NM_001039843 NM_146191 RefSeq (protein) NP_078928 NP_666303 Location (UCSC) Chr 15: 100.92 – 101.08 Mb Chr 7: 65.88 – 66.04 Mb PubMed search [3] [4]
Wikidata
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