LRRK1

LRRK1
Identifiers
Aliases	LRRK1, RIPK6, Roco1, leucine-rich repeat kinase 1, leucine rich repeat kinase 1, OSMD
External IDs	OMIM: 610986; MGI: 2142227; GeneCards: LRRK1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	101,078,257 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	66,038,098 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; transverse colon; ; spleen; ; monocyte; ; mucosa of transverse colon; ; minor salivary glands; ; skin of leg; ; rectum; ; stromal cell of endometrium;
	Top expressed in
	right lung lobe; ; transitional epithelium of urinary bladder; ; left lung; ; medullary collecting duct; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; conjunctival fornix; ; mesenteric lymph nodes; ; stroma of bone marrow; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein kinase activity; GTP binding; protein binding; ATP binding; metal ion binding; identical protein binding; protein serine/threonine kinase activity; signal transducer activity;
Cellular component	mitochondrion; cytoplasm; cytosol;
Biological process	positive regulation of canonical Wnt signaling pathway; osteoclast development; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of intracellular signal transduction; bone resorption; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; intracellular signal transduction; protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	79705
	233328
	ENSG00000154237
	ENSMUSG00000015133
	Q38SD2
	Q3UHC2
	NM_024652; NM_001039843
	NM_146191
	NP_078928
	NP_666303
	Wikidata
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