LRRN2

Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.^[5][6]

AliasesLRRN2, FIGLER7, GAC1, LRANK1, LRRN5, leucine rich repeat neuronal 2

External IDsOMIM: 605492; MGI: 106037; HomoloGene: 21274; GeneCards: LRRN2; OMA:LRRN2 - orthologs

Chr.Chromosome 1 (human)^[1]

End204,685,738 bp^[1]

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LRRN2
Identifiers
Aliases	LRRN2, FIGLER7, GAC1, LRANK1, LRRN5, leucine rich repeat neuronal 2
External IDs	OMIM: 605492; MGI: 106037; HomoloGene: 21274; GeneCards: LRRN2; OMA:LRRN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 204,617,170 bp[1] End 204,685,738 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 132,808,011 bp[2] End 132,867,743 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Region I of hippocampus proper Brodmann area 10 Epithelium of choroid plexus ventricular zone nucleus accumbens anterior pituitary cingulate gyrus anterior cingulate cortex ganglionic eminence Top expressed in lateral geniculate nucleus medial dorsal nucleus dentate gyrus dentate gyrus of hippocampal formation granule cell subiculum medial geniculate nucleus primary visual cortex anterior amygdaloid area ventromedial nucleus dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity Cellular component integral component of membrane membrane extracellular space extracellular matrix Biological process cell adhesion axonogenesis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10446 16980 Ensembl ENSG00000170382 ENSMUSG00000026443 UniProt O75325 Q6PHP6 RefSeq (mRNA) NM_006338 NM_201630 NM_010732 RefSeq (protein) NP_006329 NP_963924 NP_034862 Location (UCSC) Chr 1: 204.62 – 204.69 Mb Chr 1: 132.81 – 132.87 Mb PubMed search [3] [4]
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The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[6]