LY-320,135

LY-320,135 is a drug used in scientific research which acts as a selective antagonist of the cannabinoid receptor CB₁. It was developed by Eli Lilly and Company in the 1990s.

CAS Number

• 176977-56-3

PubChem CID

• 5311257

IUPHAR/BPS

• 742

ChemSpider

• 4470772

Quick facts Identifiers, CAS Number ...

LY-320,135

Identifiers
IUPAC name 4-[6-methoxy-2-(4-methoxyphenyl)1-benzofuran-3-carbonyl]benzonitrile
CAS Number	176977-56-3
PubChem CID	5311257
IUPHAR/BPS	742
ChemSpider	4470772
UNII	CJY03984CT
ChEMBL	ChEMBL411481
CompTox Dashboard (EPA)	DTXSID901027464
ECHA InfoCard	100.190.302
Chemical and physical data
Formula	C24H17NO4
Molar mass	383.403 g·mol−1
3D model (JSmol)	Interactive image
SMILES c3cc(OC)ccc3-c2oc1cc(OC)ccc1c2C(=O)c4ccc(C#N)cc4
InChI InChI=1S/C24H17NO4/c1-27-18-9-7-17(8-10-18)24-22(20-12-11-19(28-2)13-21(20)29-24)23(26)16-5-3-15(14-25)4-6-16/h3-13H,1-2H3 Key:RYNSGDFWBJWWSZ-UHFFFAOYSA-N
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LY-320,135 displays fairly good selectivity, with a binding affinity for CB₁ around 70x stronger than for CB₂,^[1] but both its potency and selectivity are modest compared to newer agents, and at higher doses it also binds to a range of non-cannabinoid receptors. However LY-320,135 is still fairly widely used in research, particularly for elucidating the mechanisms by which many CB₁ antagonists act as inverse agonists at higher doses.^[2]