LY6E

LY6E
Identifiers
Aliases	LY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E
External IDs	OMIM: 601384; MGI: 106651; HomoloGene: 56411; GeneCards: LY6E; OMA:LY6E - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,023,832 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	74,831,754 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; granulocyte; ; olfactory zone of nasal mucosa; ; stromal cell of endometrium; ; placenta; ; right ovary; ; right lung; ; upper lobe of left lung; ; right frontal lobe; ; hippocampus proper;
	Top expressed in
	lactiferous gland; ; superior surface of tongue; ; gallbladder; ; corneal stroma; ; cardiac muscles; ; cardiac muscle tissue of left ventricle; ; CA3 field; ; right kidney; ; perirhinal cortex; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine receptor inhibitor activity;
Cellular component	integral component of plasma membrane; membrane; anchored component of membrane; extracellular region; plasma membrane;
Biological process	cell surface receptor signaling pathway; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	4061
	17069
	ENSG00000278032; ENSG00000160932
	ENSMUSG00000022587
	Q16553
	Q64253
	NM_002346; NM_001127213
NM_001164036; NM_001164037; NM_001164038; NM_001164039; NM_001164040;
	NM_008529; NM_001374138
	NP_001120685; NP_002337
NP_001157508; NP_001157509; NP_001157510; NP_001157511; NP_001157512;
	NP_032555; NP_001361067
	Wikidata
View/Edit Human	View/Edit Mouse

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.^[5]^[6]^[7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.^[8] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.^[9] Further research is required to validate Ly6E for translation research.