LY6E

Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene.^[5][6][7] Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues.^[8] Ly6E is associated with drug resistance and tumor immune escape in breast cancer.^[9]

AliasesLY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E

External IDsOMIM: 601384; MGI: 106651; GeneCards: LY6E

Chr.Chromosome 8 (human)^[1]

End143,023,832 bp^[1]

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LY6E
Identifiers
Aliases	LY6E, RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E
External IDs	OMIM: 601384; MGI: 106651; GeneCards: LY6E
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 143,017,982 bp[1] End 143,023,832 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 D3|15 34.29 cM Start 74,826,900 bp[2] End 74,831,754 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver granulocyte olfactory zone of nasal mucosa stromal cell of endometrium placenta right ovary right lung upper lobe of left lung right frontal lobe hippocampus proper Top expressed in lactiferous gland superior surface of tongue gallbladder corneal stroma cardiac muscles cardiac muscle tissue of left ventricle CA3 field right kidney perirhinal cortex esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function acetylcholine receptor inhibitor activity Cellular component integral component of plasma membrane membrane anchored component of membrane extracellular region plasma membrane Biological process cell surface receptor signaling pathway negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4061 17069 Ensembl ENSG00000278032 ENSG00000160932 ENSMUSG00000022587 UniProt Q16553 Q64253 RefSeq (mRNA) NM_002346 NM_001127213 NM_001164036 NM_001164037 NM_001164038 NM_001164039 NM_001164040 NM_008529 NM_001374138 RefSeq (protein) NP_001120685 NP_002337 NP_001157508 NP_001157509 NP_001157510 NP_001157511 NP_001157512 NP_032555 NP_001361067 Location (UCSC) Chr 8: 143.02 – 143.02 Mb Chr 15: 74.83 – 74.83 Mb PubMed search [3] [4]
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