At age 12, Rubin contributed a "little scat solo" to the Kenny Loggins track “If You Believe” from his 1991 album, Leap of Faith.[8][9] At age 14, she sang at the inauguration of Los Angeles mayor Richard Riordan.[8]
In 1997, she won the Music Center Spotlight Award.[8] Her first CD, an art song recording in which she is accompanied by David Wilkinson, was released in 1998.
In 2012, Rubin performed at the Kennedy Center.[11]
Rubin never learned to read Braille music, and learns all of her pieces by ear.[8]
Her orchestral repertoire includes Beethoven's Symphony No. 9, Berlioz's Les nuits d'été, Handel's Messiah, Joseph Haydn's Harmoniemesse and Mozart's Great Mass in C minor.
Her most notable theatrical roles are Elle in Poulenc's La voix humaine and Mrs Noye in Britten's Noye's Fludde.[9] Among the colleagues with whom she has worked are Graham Johnson, Frederica von Stade, John Williams, the Los Angeles Chamber Orchestra, the Rochester Chamber Orchestra and the Yale Symphony Orchestra. Venues at which she has appeared include Carnegie Hall's Weill Recital Hall,[11][13] Lincoln Center,[11] Parcol Auditorium della Musica,[11] the Ravinia Festival, the 92nd Street Y, the Wigmore Hall[11][13] and the White House.
Rubin's memoir, Do You Dream in Color? Insights from a Girl without Sight, was published by Seven Stories Press in October 2012.[11][9]
Rubin and her wife, Jennifer Rubin-Taira, jointly founded the Ohana Arts Performing Arts Festival and School in the early 2010s.[7][15][16] In fall 2015, they premiered Peace on Your Wings, a musical based on the story of Sadako Sasaki, at the school.[8][9] The piece was reprised again in 2023.[17]
In the 2010s, Rubin received a grant from Yale to develop a music curriculum that used blindfolding activities to model to sighted students what the experience of blind students is like.[7]