Leucyl-tRNA synthetase
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene.[5][6]
AliasesLARS1, Leucyl-tRNA synthetase, ILFS1, HSPC192, LARS, leucyl-tRNA synthetase 1, LRS, LEUS, LFIS, PIG44, hr025Cl, LEURS, RNTLS
External IDsOMIM: 151350; MGI: 1913808; HomoloGene: 7083; GeneCards: LARS1; OMA:LARS1 - orthologs
Function
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginyl-tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.[6]
