Leukotriene-B4 20-monooxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
Leukotriene-B4 20-monooxygenase (EC 1.14.14.94) is an enzyme that catalyzes the chemical reaction
| Leukotriene-B4 20-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.94 | ||||||||
| CAS no. | 90119-11-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The four substrates of this enzyme are leukotriene B4, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen and a proton. Its products are 20-hydroxy-leukotriene B4, oxidised NADP+, and water.[1][2][3][4]
This enzyme is a cytochrome P450 omega hydroxylase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,N ADPH:oxygen oxidoreductase (20-hydroxylating). Other names in common use include leukotriene-B4 20-hydroxylase, leucotriene-B4 omega-hydroxylase, LTB4 20-hydroxylase, and LTB4 omega-hydroxylase. It participates in arachidonic acid metabolism and contains heme.[1]
