LisH domain
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| LisH | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 n-terminal domain of lissencephaly-1 protein (lis-1) | |||||||||
| Identifiers | |||||||||
| Symbol | LisH | ||||||||
| Pfam | PF08513 | ||||||||
| InterPro | IPR013720 | ||||||||
| |||||||||
In molecular biology, the LisH domain (lis homology domain) is a protein domain found in a large number of eukaryotic proteins, from metazoa, fungi and plants that have a wide range of functions. The recently solved structure of the LisH domain in the N-terminal region of LIS1 depicted it as a novel dimerisation motif, and that other structural elements are likely to play an important role in dimerisation.[1][2][3]
The LisH domain is found in the Saccharomyces cerevisiae SIF2 protein, a component of the SET3 complex which is responsible for repressing meiotic genes In SIF2 the LisH domain has been shown to mediate dimer and tetramer formation.[4] It has been shown that the LisH domain helps mediate interaction with components of the SET3 complex.[4]