List of adverse effects of risperidone
From Wikipedia, the free encyclopedia
This is a list of adverse effects of risperidone. Risperidone, sold under the brand name Risperdal among others, is an antipsychotic.[1] It is used to treat schizophrenia, bipolar disorder, and irritability associated with autism.[1]
Common adverse effects
Common adverse effects of risperidone, occurring greater than or equal to 1%, include:[2][3][4]
- Rash (oral, adults, 1% to 4%; pediatrics, up to 11%; IM, less than 4%)
- Hyperprolactinaemia (risperidone is probably the most notorious antipsychotic for causing hyperprolactinaemia via its potent blockade of D2 receptors expressed on the lactotrophic cells of the pituitary)[5] (oral, adults, less than 1%; pediatrics, 49% to 87%; IM, less than 4%)
- Weight gain (causes less weight gain than clozapine, olanzapine and zotepine, around as much weight gain as quetiapine and more weight gain than amisulpride, aripiprazole, lurasidone, asenapine and ziprasidone)[5] (oral, adult, 8.7% to 20.9%; pediatric, 14% to 32.6%; IM, adult, 8% to 10%)
- Seborrhea
- Constipation (oral, 8% to 21%; IM, 5% to 7%)
- Diarrhoea (oral, 1% to 8%; IM, less than 4%)
- Excessive Salivation (oral, 1% to 10%; IM, 1% to 4%)
- Increased appetite (oral, adult, more than 5%; pediatric, 4% to 47%; IM, 4%)
- Indigestion (oral, 2% to 10%; IM, 6%)
- Nausea (oral, 4% to 16%; IM, 3% to 4%)
- Vomiting (oral, 10% to 25%; IM, less than 4%)
- Upper abdominal pain (oral, adult, more than 5%; pediatric, 13% to 16%)
- Xerostomia (oral, 4% to 15%; IM, up to 7%)
- Akathisia (oral, up to 10%; IM, 4% to 11%)
- Dizziness (oral, 4% to 16%; IM, 3% to 11%)
- Dyspnoea
- Asthenia
- Agitation
- Urinary incontinence
- Arthralgia
- Myalgia
- Epistaxis
- Somnolence (oral, adult, 3% to 6%; pediatric, 8% to 29% )
- Sleep disturbances
- Major depression, self harm and suicidal thoughts
- Dose-dependent extrapyramidal side effects such as dystonia (oral, adult, 3% to 5%; pediatric, 2% to 6%; IM, adult, less than 4%), tremor (oral, 2% to 12%; IM, 3% to 24%) and Parkinsonism (oral, 6% to 28%; IM, 8% to 15%)
- Blurred vision (oral, 1% to 7%; IM, 2% to 3%)
- Anxiety (oral, up to 16% IM, less than 4%)
- Cough (oral, adults, 2%; pediatrics, 24%; IM, 2% to 4%)
- Nasal congestion (oral, adult, 4% to 6%; pediatric, 13%)
- Nasopharyngitis (oral, adult, 3% to 4%; pediatric, 21%)
- Pain in the throat (oral, adult, more than 5%; pediatric, 3% to 10%)
- Upper respiratory tract infection (oral, 2% to 8%; IM, 2% and 6%)
- Fatigue (oral, adult, 1% to 3%; pediatric, 18% to 42%; IM, 3% to 9%)
- Generalised pains (IM, 1% to 4%)
- Gynecomastia[6][7]
- Galactorrhea[8]
- Retrograde ejaculation
Note: The percentage provided next to the adverse effect is the incidence of that adverse effect according to DrugPoint.[2]
Rare adverse effects (but not necessarily causally related)
Rare adverse effects of risperidone, occurring less than 1%, include:[2][3][4]
- Prolonged QT interval
- Sudden cardiac death
- Syncope (oral, up to 1%; IM, up to 2%)
- Diabetic ketoacidosis
- Hypothermia
- Pancreatitis
- Agranulocytosis
- Neutropenia
- Leukopenia
- Thrombocytopenia
- Thrombotic thrombocytopenic purpura
- Stroke (oral, less than 5%; IM, less than 4%)
- Seizure (oral, 0.3%; IM, 0.3%)
- Tardive dyskinesia (oral, less than 5%; IM, less than 4%)
- Priapism
- Pulmonary embolism
- Neuroleptic malignant syndrome (oral, adults, less than 1%; pediatrics, less than 5%)
- Anorexia
- Hypoaesthesia
- Impaired concentration
- Sexual dysfunction
- Angioedema
- Intestinal obstruction
- Megacolon
- Oedema
- Hyponatraemia
Note: The percentage provided next to the adverse effect is the incidence of that adverse effect according to DrugPoint.[2]