List of disasters in Maine by death toll
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This is a list of disasters that have occurred in Maine organized by death toll. Historically documented events that caused 10 or more deaths are included.

List
Notes:
- Some of the events occurred prior to Maine becoming a U.S. state.
- Acts of war are excluded, such as battles of the American Revolutionary War in Maine.
- Some of the events occurred in the Atlantic Ocean, at varying distances from land.
| Year | Event | Type | Death toll | Location | Sources |
|---|---|---|---|---|---|
| 1864 | Wreck of the steamship Bohemian [a] | Accident – ship | 42[b] | off Cape Elizabeth | [2][3][4][5][6] |
| 1941 | Disappearance of the excursion cruiser Don [c] | Accident – ship | 34 | off Bailey Island | [7] |
| 1850 | Maine Insane Asylum fire | Fire | 28 | Augusta | [8] |
| 1919 | Onawa train wreck | Accident – railroad | 23 | Onawa | [9] |
| 1899 | Mount Desert Ferry gangway collapse | Drowning | 20 | Bar Harbor | [10] |
| 1944 | South Portland A-26 Invader crash | Accident – aircraft | 19 | South Portland | [11] |
| 2023 | 2023 Lewiston shootings | Mass shooting | 19 | Lewiston | [12] |
| 1908 | Schooner Fame / steamship Boston collision[d] | Accident – ship | 18 | off Seguin Light | [13] |
| 1807 | Wreck of the Hanover | Accident – ship | 17 | off Pond Island | [14] |
| 1945 | Lacoste Babies Home fire | Fire | 17 | Auburn | [15] |
| 1979 | Downeast Airlines Flight 46 | Accident – aircraft | 17 | Rockland | [16] |
| 1807 | Wreck of the schooner Charles [e] | Accident – ship | 16 | off Richmond Island | [17] |
| 1920 | Chesuncook Lake drownings | Accident – boat | 16 | Bangor | [18] |
| 1947 | Great Fires of 1947 | Wildfires | 16 | Statewide | [19] |
| 1807 | Wreck of the Sagunto | Accident – ship | 14 | off Smuttynose Island | [20] |
| 1902 | Isles of Shoals boating accident | Accident – boat | 14 | off Appledore Island | [21] |
| 2002 | Allagash Wilderness Waterway van accident | Drowning | 14 | Millinocket | [22] |
| 1860 | Wreck of the schooner Neptune's Bride [f] | Accident – ship | 12 | off Criehaven | [23][24] |
| 1936 | Gardner Lake Tragedy | Accident – boat | 12 | Marion Township | [25] |
| 1849 | Disappearance of the schooner Levi Woodbury [g] | Accident – ship | 10 | off Boon Island | [26][27] |
| 1920 | Wreck of the SS Polias [h] | Accident – ship | 10 | off Port Clyde | [28] |
| 1944 | North Oxford B-17 Flying Fortress crash[i] | Accident – aircraft | 10 | North Oxford | [29][30] |
| 1947 | Brockton drownings at Moosehead Lake | Accident – boat | 10 | Greenville | [31] |