Nevada State Route 601

Main Street (SR 601) begins at an intersection with South Las Vegas Boulevard and Saint Louis Avenue. At the intersection with Oakey Boulevard, former SR 601 becomes a one-way pair; the northbound direction retains the name Main Street, while the southbound direction is signed as Commerce Street. Further north, the pair intersects Charleston Boulevard; furthermore, the eastern terminus of SR 159's central segment is at Commerce Street. Main Street provides access to a pedestrianized Boulder Avenue and the Burlesque Hall of Fame. About 400 feet (120 m) north of Gass Avenue, the one-way pair merges as Main Street. It then provides access to the Carolyn G. Goodman Plaza, the Las Vegas City Hall, and numerous hotels and casinos. The intersection of Main Street and the Fremont Street Experience is the mathematical origin of Las Vegas's street address grid.

Main Street then goes under I-11 / US 93 / US 95 (former I-515) before intersecting Bonanza Road (SR 579, former US 95) and Washington Avenue (unsigned SR 578) before serving as the eastern boundary of the portion of the Las Vegas Paiute Tribe in Las Vegas. After an intersection with Owens Avenue, Main Street (and, thus, former SR 601) ends at a roundabout with Las Vegas Boulevard and North 5th Street.

Main Street is part of the National Highway System (NHS) between Charleston Boulevard and Stewart Avenue. The NHS is a system of highways considered important to the country's defense. The NHS corridor continues along Stewart Avenue until intersecting Las Vegas Boulevard. It turns north to end at I-11.

The entire route is in Las Vegas, Clark County.

mi	km	Destinations	Notes
0.0	0.0	Saint Louis Avenue east	Continuation beyond southern terminus
		SR 604 (South Las Vegas Boulevard)	Southern terminus of Main Street and SR 601
		Oakey Boulevard	One-way pair: northbound direction continues as Main Street, while southbound direction is Commerce Street
		Wyoming Avenue
		SR 159 (Charleston Boulevard)	Southern terminus of NHS route; Commerce Street currently serves as the eastern terminus of SR 159's central segment
		400 ft (120 m)[2] north of Gass Avenue	End of one-way pair
		Bonneville Avenue	Provides access to Bonneville Transit Center
		Goodman Way east	Pedestrian street; serves Las Vegas City Hall; western terminus of Goodman Way; former Clark Avenue
		Fremont Street Experience east	Pedestrian street; western terminus of Fremont Street Experience; Main Street changes signing from "South Main Street" to "North Main Street"
		Stewart Avenue east	NHS route turns east onto Stewart Avenue; western terminus of Stewart Avenue
		SR 579 (Bonanza Road)	Former US 95 / SR 5
		Washington Avenue (SR 578)
		Paiute Circle	Provides access to Las Vegas Paiute Tribe
		Owens Avenue
		SR 604 (North Las Vegas Boulevard) / 5th Street north	Roundabout; northern terminus of Main Street and SR 601; southern terminus of 5th Street
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Route transition