List of investigational aggression drugs
From Wikipedia, the free encyclopedia
This is a list of investigational aggression drugs, or drugs that are currently under development for clinical use in the treatment of aggression but are not yet approved. Drugs used to treat aggression may also be known as "serenics".[1]
Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
This list was last comprehensively updated in February 2025. It is likely to become outdated with time.
Under development
Phase 3
Phase 2
Preclinical
Not under development
No development reported
- Eltoprazine (DU-28853) – serotonin 5-HT1A and 5-HT1B receptor agonist and serotonin 5-HT2C receptor antagonist[11][1]
- Zolmitriptan (ML-004) – serotonin 5-HT1B and 5-HT1D receptor agonist[12][13][14]
Development discontinued
- Batoprazine – serotonin 5-HT1A and 5-HT1B receptor agonist[15][1]
- Mibampator (LY-451395) – ionotropic glutamate AMPA receptor positive allosteric modulator[16]
- Olanzapine intranasal (INP-105; POD olanzapine) – atypical antipsychotic (non-selective monoamine receptor modulator)[17]
- Risperidone extended-release (Risperisphere) – atypical antipsychotic (non-selective monoamine receptor modulator)[18]
Formal development never or not yet started
- Antiandrogens (e.g., cyproterone acetate, medroxyprogesterone acetate, GnRH modulators)[19][20][21][22]
- Other serotonin 5-HT1A and 5-HT1B receptor agonists (e.g., fluprazine)[1][23]
- Selective 5-HT1B receptor agonists (e.g., anpirtoline, CP-94253)[24][25][26][27]
- Serotonin 5-HT1B and 5-HT1D receptor agonists (e.g., PGI-7043)[28]
- Serotonin 5-HT2B receptor antagonists (e.g., MW073)[29][30]
- Serotonin 5-HT2C receptor agonists (e.g., lorcaserin)[31][32][33][34]
- Serotonin releasing agents (e.g., fenfluramine)[35]
- Trace amine-associated receptor 1 (TAAR1) agonists (e.g., RO5263397)[36][24]
Clinically used drugs
Approved drugs
- Olanzapine (Zyprexa) – atypical antipsychotic (non-selective monoamine receptor modulator)[37]
- Paliperidone (Invega) – atypical antipsychotic (non-selective monoamine receptor modulator)[38]
- Risperidone (Risperdal) – atypical antipsychotic (non-selective monoamine receptor modulator)[39]
Off-label drugs
- α2-Adrenergic receptor agonists (e.g., clonidine, dexmedetomidine, guanfacine)[40][41]
- Anticonvulsants (e.g., valproic acid, divalproex, carbamazepine, oxcarbazepine, phenytoin, lamotrigine, topiramate, gabapentin, tiagabine)[42][43][41][44][45][46][47][48]
- Antidepressants (e.g., selective serotonin reuptake inhibitors (SSRIs) like sertraline)[49][50] (but may exacerbate aggression)[51][52][53]
- Benzodiazepines (e.g., diazepam, lorazepam, midazolam)[54][55][41] (but may exacerbate aggression)[56][57][58][52]
- Beta blockers (β-adrenergic receptor antagonists) (e.g., propranolol, pindolol, nadolol)[59][60]
- Cannabinoids (e.g., cannabis, dronabinol, nabilone)[61][62][63]
- Lithium – mood stabilizer with unknown mechanism of action[42][64]
- Norepinephrine reuptake inhibitors (NRIs) (e.g., atomoxetine)[40]
- Other antipsychotics (e.g., aripiprazole, chlorpromazine, droperidol, haloperidol, quetiapine, thioridazine)[42][55][65][66][41]
- Psychostimulants (e.g., amphetamine, methylphenidate)[40][42][67][68][43][60] (but may exacerbate aggression)[67][52]
See also
- List of investigational drugs
- List of investigational agitation drugs
- List of investigational antipsychotics
- List of investigational borderline personality disorder drugs
- List of investigational autism and pervasive developmental disorder drugs
- Serenic (antiaggressive drug)
- Anger § Medication therapy
- Entactogen