List of investigational fibromyalgia drugs

This is a list of investigational fibromyalgia drugs, or drugs that are currently under development for clinical use in the treatment of fibromyalgia but are not yet approved.

Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action [Reference]".

This list was last comprehensively updated in September 2025. It is likely to become outdated with time.

Preregistration

Esreboxetine ((S,S)-Reboxetine; AXS-14; PNU-165442G) – norepinephrine reuptake inhibitor (NRI)

Phase 3

Pregabalin controlled release (GRO-12; Lyrica CR; Pregabalin CR; Pregabalin ER) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand)

Phase 2

Celecoxib/famciclovir (famciclovir/celecoxib; IMC-1) – combination of celecoxib (COX inhibitor/NSAID) and famciclovir (antiviral)
Mirtazapine (Avanza; Azamianserin; ME-2040; Mepirzapin; Norset; ORG-3770; Promyrtil; Reflex; Remergil; Remergon; Remeron; Rexer; Zispin) – tetracyclic antidepressant (TeCA) (non-selective monoamine receptor modulator and other actions)
ONO-1110 – endocannabinoid synthesis regulator and indirect cannabinoid receptor modulator
Opiranserin (Unafra; VVZ-000149; VVZ-149) – glycine transporter 2 (GlyT2) blocker, purine P2X₃ receptor antagonist, and serotonin 5-HT_2A receptor antagonist
Psilocybin (PFN™; TRP-8802; TRP-8803; TRP-8804; TRYP-0082) – non-selective serotonin receptor agonist and psychedelic hallucinogen ^[1]^[2]
Rozanolixizumab (Rystiggo; UCB-7665) – monoclonal antibody against neonatal Fc receptor (FcRn)

Research

Celecoxib/valacyclovir (IMC-2; valacyclovir/celecoxib) – combination of celecoxib (COX inhibitor/NSAID) and valacyclovir (antiviral)

Not under development

Suspended

ETX-155 – GABA_A receptor positive allosteric modulator and neurosteroid

No development reported

ASP-0819 (ASP0819) – calcium-activated potassium channel opener
CT-38 – corticotropin-releasing factor CRF₂ receptor agonist
Elcubragistat (ABX-1431; Lu-AG06466) – monoacylglycerol lipase (MAGL) inhibitor
Galcanezumab (Emgality; LY-2951742) – monoclonal antibody against calcitonin gene-related peptide (CGRP)
Lacosamide (ADD-234037; Erlosamide; Harkoseride; SPM-927; SPM-929; Vimpat; Vimpato) – various actions
Pregabalin controlled release (Pregabalin XR; Regabatin XR) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand)
Research programme: cannabis extract therapeutics - Cannabis Science – cannabinoid receptor modulators
Research programme: pregabalin gastric-retentive - ProTect (NPRx-1000; PRTT-200) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand)
Ropinirole (Adartrel; Repreve; Requip) – dopamine D₂, D₃, and D₄ receptor agonist
SER-282 – undefined mechanism of action
Somatropin (Nutrophin; Nutropin; SMP-140) – growth hormone (GH) replacement
Sunobinop (IMB-115; IT-1315; RSC-117957; S-117957; V-117957) – nociceptin receptor agonist

Discontinued

AD-337 – serotonin–norepinephrine reuptake inhibitor (SNRI)
Ampreloxetine (TD-9855) – serotonin–norepinephrine reuptake inhibitor (SNRI)
ASP-8062 – GABA_B receptor positive allosteric modulator
Desvenlafaxine (DVS-233; MD-120; O-desmethylvenlafaxine; Pristiq; WY-45233) – serotonin–norepinephrine reuptake inhibitor (SNRI)
Droxidopa (3,4-dihydroxyphenylserine; 3,4-threo-DOPS; DOPS; Northera; threo-DOPS) – norepinephrine precursor and indirect non-selective adrenergic receptor agonist
Eslicarbazepine acetate (Aptiom; BIA 2-093; ESL; Exalief; SEP-0002093; SEP-2093; Stedesa; Zebinix) – sodium channel blocker
Faxeladol (GRT-9906; GRT9906) – μ-opioid receptor (MOR) agonist and serotonin–norepinephrine reuptake inhibitor (SNRI) (tramadol analogue)
Fremanezumab (Ajovy; LBR-101; PF-04427429; PF-4427429; RN-307; TEV-48125) – monoclonal antibody against calcitonin gene-related peptide (CGRP)
Galantamine (galanthamine; GP-37267; Nivalin; R-113675; Razadyne; Reminyl) – acetylcholinesterase inhibitor
Ibutamoren (L-163191; LUM-201; MK-0677; MK-677; Oratrope) – ghrelin receptor agonist and growth hormone secretagogue
Interferon α2a (IFN-α lozenges; MOR-22; Veldona) – interferon α stimulant and immunomodulator
Nabilone (Cesamet) – cannabinoid CB₁ and CB₂ receptor agonist
PF-738502 – undefined mechanism of action
Pramipexole (BI-Sifrol; Daquiran; Mirapex; Mirapexin; Pexola; Sifrol; SND-919; SND-919Y) – dopamine D₂, D₃, and D₄ receptor agonist
Pregabalin sustained release (EASOPSRTFP) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand)
Radafaxine (GW-353162; (2S,3S)-hydroxybupropion) – norepinephrine–dopamine reuptake inhibitor (NDRI)
Research programme: fibromyalgia therapies - Cypress Bioscience/Georgetown University – undefined mechanism of action
Rotigotine transdermal (Leganto; N-0437; N-0923; Neupro; Nubrenza; SPM-962) – non-selective dopamine receptor agonist and other actions
Sodium oxybate (γ-hydroxybutyrate; GHB; JZP-6; KEY-10; Xyrem) – GABA_B receptor agonist and GHB receptor agonist ^[3]^[4]
Terguride (Dironyl; Mysalfon; SH-406; Teluron; Transdihydrolisuride; VUFB-6638; ZK-31224) – non-selective dopamine receptor agonist, non-selective serotonin receptor modulator, and other actions
Tizanidine (AN-021A; AN-021; DS-103282-CH; DS-103282; Sirdalud; Ternelin; Zanaflex) – α₂-adrenergic receptor agonist
Ubidecarenone (Bio-Quinone Q10; Coenzyme Q10; CoQ10; Neuquinon; Q-Gel; UbiQGel; Ubiquinone; Vitaline) – antioxidant and immunomodulator
ZYN-001 (δ⁹-THC D-glyceric acid ester; THC prodrug transdermal patch) – cannabinoid CB₁ and CB₂ receptor agonist

Clinically used drugs

Approved

Cyclobenzaprine (KRL-102; TNX-102; Tonmya) – tricyclic antidepressant (TCA) (non-selective monoamine reuptake inhibitor and monoamine receptor modulator)
Duloxetine (Ariclaim; Cymbalta; LY-227942; LY-248686; Xeristar; Yentreve) – serotonin–norepinephrine reuptake inhibitor (SNRI)
Milnacipran (Dalcipran; F-2207; Impulsor; Ixel; Joncia; Midacipran; Midalcipran; Savella; TN-912; Toledomin) – serotonin–norepinephrine reuptake inhibitor (SNRI)
Pregabalin (CI-1008; isobutylgaba; Lyrica; PD-144723) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand)

Off-label drugs

Anticonvulsants (e.g., lacosamide)^[5]
Cannabinoids (cannabinoid receptor modulators) (e.g., cannabis, tetrahydrocannabinol (THC), cannabidiol (CBD), nabilone)^[6]^[5]
Capsaicin – transient receptor potential vanilloid receptor 1 (TRPV1) agonist^[7]^[8]
Carisoprodol (Soma) – muscle relaxant^[9]^[10]
Gabapentinoids (α₂δ subunit-containing voltage-gated calcium channel ligands) (e.g., gabapentin, gabapentin enacarbil, mirogabalin)^[11]^[12]^[5]
Hypnotics (e.g., zolpidem)^[11]
Melatonin – melatonin receptor agonist^[13]
Monoamine oxidase inhibitors (MAOIs) (e.g., moclobemide, pirlindole)^[14]^[8]
Non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen, aspirin)
Paracetamol (acetaminophen) – analgesic^[11]
Selective serotonin reuptake inhibitors (SSRIs) (e.g., citalopram, fluoxetine, paroxetine)^[8]
Sodium oxybate (γ-hydroxybutyrate; GHB; Xyrem) – GABA_B receptor agonist and GHB receptor agonist^[3]^[5]^[4]
Serotonin–norepinephrine reuptake inhibitors (SNRIs) (e.g., desvenlafaxine, levomilnacipran, venlafaxine)
Tetracyclic antidepressants (TeCAs) (e.g., mirtazapine)^[15]
Tizanidine (Zanaflex) – α₂-adrenergic receptor agonist^[11]
Tramadol (Tramal) – weak μ-opioid receptor (MOR) agonist and serotonin–norepinephrine reuptake inhibitor (SNRI)^[16]^[17]
Tricyclic antidepressants (TCAs) (e.g., amitriptyline)^[11]^[8]
Tropisetron – serotonin 5-HT₃ receptor antagonist^[5]

v t e Neuropathic pain and fibromyalgia pharmacotherapies
Monoaminergics	SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine, milnacipran) TCAsTooltip Tricyclic antidepressants (e.g., amitriptyline, nortriptyline, dosulepin) Opioid MRIsTooltip monoamine reuptake inhibitors (e.g., tapentadol, tramadol)
Ion channel blockers	Anticonvulsants (e.g., gabapentin, pregabalin, mirogabalin, carbamazepine, oxcarbazepine, lacosamide, lamotrigine) Local anesthetics (e.g., lidocaine) Mexiletine TCAsTooltip Tricyclic antidepressants (e.g., amitriptyline, nortriptyline, desipramine) Ziconotide
Others	Alpha lipoic acid Benfotiamine Botulinum toxin A Bupropion Cannabinoids (e.g., cannabis, dronabinol, nabilone) NMDA receptor antagonists (e.g., ketamine, dextromethorphan, methadone) Opioids (e.g., hydrocodone, morphine, oxycodone, methadone, buprenorphine, tramadol, tapentadol) Sodium oxybate (GHB)