List of largest cities in the Midwestern United States by population
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This is a list of the largest cities in the Midwestern United States (Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri Nebraska, North Dakota, Ohio, South Dakota, and Wisconsin) over 100,000 people, based on estimates for July 1, 2024, by the United States Census Bureau.[1]

The Midwest Region has a collective population of 68,995,685 in 12 states, based on the 2020 United States census.[2] Sizeable cities in this region include Chicago, Indianapolis, Detroit, Louisville, and Minneapolis, among others. The population figures here are for the incorporated areas of the listed cities, as opposed to metropolitan areas, urban areas, or counties.
List
| State capital | |
| State's largest city | |
| State capital and largest city |