List of mayors of the 50 largest cities in the United States

This is a list of mayors of the 50 largest cities in the United States, ordered by their populations as of July 1, 2022, as estimated by the United States Census Bureau.^[1][2] These 50 cities have a combined population of 49.6 million, or 15% of the national population.

Honolulu, Indianapolis, Jacksonville, Louisville, and Nashville have consolidated city-county governments where the mayor is elected by residents of the entire county, not just that of the city proper; in these cases the population and respective rank are for the whole county.

In some jurisdictions, mayors are officially elected on a nonpartisan basis; however, the candidate's party affiliation that is known through their political history, self-declaration, or state party support is listed below.

The breakdown of mayoral political parties is 41 Democrats, 7 Republicans, and 2 Independents (one elected with state Democratic support).