List of number-one singles of 2021 (Portugal)

The Portuguese Singles Chart ranks the best-performing singles in Portugal, as compiled by the Associação Fonográfica Portuguesa.

Week	Song	Artist	Reference
1/2021	"São Paulo"	Yuri Nr5	[1]
2/2021	"Drivers License"	Olivia Rodrigo	[2]
3/2021			[3]
4/2021			[4]
5/2021			[5]
6/2021			[6]
7/2021			[7]
8/2021			[8]
9/2021			[9]
10/2021			[10]
11/2021	"Without You"	The Kid Laroi	[11]
12/2021	"Peaches"	Justin Bieber featuring Daniel Caesar and Giveon	[12]
13/2021			[13]
14/2021	"Montero (Call Me by Your Name)"	Lil Nas X	[14]
15/2021			[15]
16/2021			[16]
17/2021			[17]
18/2021			[18]
19/2021			[19]
20/2021			[20]
21/2021	"Good 4 U"	Olivia Rodrigo	[21]
22/2021			[22]
23/2021			[23]
24/2021	"Bipolar"	MC Davi, MC Pedrinho and MC Don Juan	[24]
25/2021			[25]
26/2021			[26]
27/2021	"Beggin'"	Måneskin	[27]
28/2021			[28]
29/2021			[29]
30/2021			[30]
31/2021	"Industry Baby"	Lil Nas X and Jack Harlow	[31]
32/2021			[32]
33/2021			[33]
34/2021			[34]
35/2021			[35]
36/2021	"Pepas"	Farruko	[36]
37/2021			[37]
38/2021	"Industry Baby"	Lil Nas X and Jack Harlow	[38]
39/2021	"Love Nwantiti (Ah Ah Ah)"	CKay featuring Joeboy and Kuami Eugene	[39]
40/2021			[40]
41/2021			[41]
42/2021			[42]
43/2021			[43]
44/2021			[44]
45/2021			[45]
46/2021			[46]
47/2021			[47]
48/2021			[48]
49/2021			[49]
50/2021			[50]
51/2021			[51]
52/2021			[52]