List of number-one songs of 2010 (Mexico)

In 2010, nine songs reached number one on the General chart; all of these songs were entirely in Spanish. Four acts achieved their first number-one song in Mexico: Camila, Enrique Iglesias, Juan Luis Guerra and Marco Antonio Solís.

"Mientes" by Camila and "Cuando me enamoro" by Enrique Iglesias & Juan Luis Guerra were the longest-running General number-ones of the year, both staying at the top position for thirteen consecutive weeks each. "Cuando me enamoro" was also the best-performing song of the year.

The yellow background indicates the best-performing song of 2010.[3]

Issue date	Song	Artist(s)	Ref.
January 3	"Estuve"	Alejandro Fernández	[4]
January 10	"Mientes"	Camila
January 17			[5]
January 24
January 31			[6]
February 7			[7]
February 14			[8]
February 21			[7]
February 28
March 7
March 14			[9]
March 21			[10]
March 28			[11]
April 4			[12]
April 11	"Gitana"	Shakira	[11]
April 18			[13]
April 25
May 2	"Mi princesa"	David Bisbal	[14]
May 9
May 16			[15]
May 23	"Gitana"	Shakira	[16]
May 30	"Aléjate de mí"	Camila	[17]
June 6
June 13
June 20
June 27
July 4	"Cuando me enamoro"	Enrique Iglesias & Juan Luis Guerra	[18]
July 11			[19]
July 18
July 25			[20]
August 1			[21]
August 8
August 15
August 22
August 29
September 5
September 12
September 19			[22]
September 26
October 3	"¿A donde vamos a parar?"	Marco Antonio Solís	[23]
October 10			[24]
October 17	"Bésame"	Camila
October 24			[25]
October 31			[26]
November 7
November 14			[27]
November 21			[28]
November 28
December 5			[29]
December 12			[30]
December 19	"Tú sabes quién"	Alejandro Fernández
December 26			[31]

Issue date	Song	Artist(s)	Ref.
January 31	"Mientes"	Camila	[6]
February 14			[8]
March 14			[9]
March 21			[10]
April 4			[12]
April 11	"Gitana"	Shakira	[11]
April 18			[13]
April 25
May 2			[14]
May 9
May 16	"Aléjate de mí"	Camila	[15]
May 23			[16]
May 30			[17]
June 6
June 13
June 20
June 27
July 4			[18]
September 5	"Cuando me enamoro"	Enrique Iglesias & Juan Luis Guerra	[21]
September 12
September 26	"Tu voz"	Erik Rubín	[22]
October 3			[23]
October 17	"Bésame"	Camila	[24]
October 24			[25]
November 7			[26]
November 14			[27]
December 19			[30]
December 26			[31]

Issue date	Song	Artist(s)	Ref.
January 31	"Me gusta todo de ti"	Banda el Recodo	[6]
February 7			[7]
February 14			[8]
March 14			[9]
March 21	"Más adelante"	La Arrolladora Banda El Limón	[10]
March 28	"Bandida"	Alejandro Fernández	[7]
April 4			[12]
April 11			[11]
April 18			[13]
April 25
May 2			[14]
May 9	"Dime que me quieres"	Banda el Recodo
May 16			[15]
May 23			[16]
June 20			[17]
June 27
July 4			[18]
September 5	"Niña de mi corazón"	La Arrolladora Banda El Limón	[21]
September 12	"¿A donde vamos a parar?"	Marco Antonio Solís
September 26			[23]
October 3
October 24			[25]
November 14			[27]
December 19	"Te amo y te amo"	La Adictiva Banda San José de Mesillas	[31]
December 26	"Disponible para mí"	La Arrolladora Banda El Limón

Issue date	Song	Artist(s)	Ref.
January 31	"Bad Romance"	Lady Gaga	[6]
February 7			[7]
February 14			[8]
March 14			[9]
March 21			[10]
March 28			[7]
April 4	"Tik Tok"	Kesha	[12]
April 11			[11]
April 18			[13]
April 25
May 2	"Telephone"	Lady Gaga ft. Beyoncé	[14]
May 9
May 16			[15]
May 23			[16]
June 20			[17]
June 27
July 4	"Gettin' Over You"	David Guetta & Chris Willis ft. Fergie & LMFAO	[18]
September 5	"Alejandro"	Lady Gaga	[21]
September 12
October 3			[23]
October 24			[25]
November 7			[27]
November 14	"Love the Way You Lie"	Eminem
December 19	"The Time (Dirty Bit)"	The Black Eyed Peas	[31]
December 26

• List of number-one albums of 2010 (Mexico)
• List of top 20 songs for 2010 in Mexico