List of number-one songs of 2021 (Nigeria)

The TurnTable Top 50 ranked the best-performing singles in Nigeria between 2020 and mid-2022.^[1] Launched on 9 November 2020, the chart employed a three-metric methodology in 2021 that combined radio airplay from 54 stations tracked by Radiomonitor, television airplay from five cable channels monitored through Radiomonitor and media planning service, and streaming data from three freemium platforms including YouTube, Boomplay Music, and Audiomack.^[2] The chart was compiled on Wednesdays and published every Monday by TurnTable magazine.^[1] In March 2022, its data sources were expanded to include Apple Music, Deezer, and Spotify, and by July, the chart had transitioned from Top 50 to Top 100.^[3]

Thirteen singles reached number one on the TurnTable Top 50 chart during 2021. Four of the thirteen were collaborations, with fourteen acts topping the chart as lead or featured artists. Joeboy's "Sip (Alcohol)" was the year's longest-running number-one song, spending ten consecutive weeks at the summit between October and December. Omah Lay led the chart in 2021, accumulating thirteen weeks at number one across three songs: "Godly," which opened the year with six consecutive weeks at the top, "Forever (Remix)", and "Understand", making him the only act to score more than two chart-toppers, while Kizz Daniel earned two with "Lie" and "Pour Me Water", which spent seven weeks and one week at number one, respectively.

Teni's "For You", featuring Davido, also logged seven non-consecutive weeks at number one from February to April, becoming the year's longest-running collaboration. The song became both the longest-running number one by a female artist in TurnTable history and the first song by a lead female artist to debut at number one. Gyakie became the first Ghanaian artist to top the chart when "Forever (Remix)" reached number one in March, remaining there for four weeks. Ayra Starr's "Bloody Samaritan" became the first solo song by a female artist to reach the top position. The year concluded with Fireboy DML and Ed Sheeran's "Peru" reaching number one in the final week of December, a position it would continue to hold into 2022.