Lometraline

Other namesN,N-dimethyl-8-chloro-5-methoxy-1-aminotetralin

ATC code

• None

CAS Number

• 39951-65-0
  34552-78-8 (hydrochloride)

PubChem CID

• 34789

Lometraline

Clinical data
Other names	N,N-dimethyl-8-chloro-5-methoxy-1-aminotetralin
ATC code	None
Identifiers
IUPAC name 8-chloro-5-methoxy-N,N-dimethyl-1,2,3,4-tetrahydro-1-naphthalenamine
CAS Number	39951-65-0 34552-78-8 (hydrochloride)
PubChem CID	34789
ChemSpider	32014
UNII	V78B234QEY
KEGG	D02669
ChEMBL	ChEMBL2111119
CompTox Dashboard (EPA)	DTXSID70865981
Chemical and physical data
Formula	C13H18ClNO
Molar mass	239.74 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1ccc(OC)c2c1C(N(C)C)CCC2
InChI InChI=1S/C13H18ClNO/c1-15(2)11-6-4-5-9-12(16-3)8-7-10(14)13(9)11/h7-8,11H,4-6H2,1-3H3 Key:MTWNWMGGMZUIMZ-UHFFFAOYSA-N

Lometraline (INN; developmental code name CP-14,368) is a drug and an aminotetralin derivative.^[1] A structural modification of tricyclic neuroleptics, lometraline was originally patented by Pfizer as an antipsychotic, tranquilizer, and antiparkinsonian agent.^[2][3] However, it was instead later studied as a potential antidepressant and/or anxiolytic agent, though clinical studies revealed no psychoactivity at the doses used and further investigation was suspended.^[1][4][5] Further experimental modifications of the chemical structure of lometraline resulted in the discovery of tametraline, a potent inhibitor of the reuptake of dopamine and norepinephrine, which in turn led to the discovery of the antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI).^[6]