Prior to entering politics, Saine worked as a regional sales director. She was also a member of the Dacono City Council.[5] She was elected to the Colorado House of Representatives in November 2012 and assumed office in January 2013. During her final term in the House, Saine served as a vice chair of the Legislative Audit Committee.[6]
When Republican Representative Jon Becker left the Legislature and left the District 63 seat open, Saine won the June 26, 2012, Republican primary with 3,444 votes (93%) against a write-in candidate,[7] and won the November 6, 2012 General election with 21,162 votes (56%) against Democratic nominee Tim Erickson[8] who had run for a House seat in 2004.
In December 2017, Saine was arrested at Denver International Airport for carrying a loaded handgun through security. Saine said she did not know that her gun was in her purse when she went to the airport. No charges were pressed.[9][10]
In January 2019, Saine was criticized by Democrat Leslie Herod for inaccurately equating the lynchings of African-Americans with that of whites during the Reconstruction era following the Civil War.[11]
In December 2020, in her role as chair of the Legislative Audit Committee, she held a hearing to examine allegations of fraud and irregularities during Colorado's 2020 elections amid Donald Trump's false claims of fraud in the presidential election.[12][13] The hearing ultimately found no evidence of electoral irregularities or fraud.[13]
In 2020, Saine was term-limited as a state representative. In the 2020 general election, she was elected to represent District 3 of the Weld County Board of County Commissioners.[14]
In November 2021, Saine announced her candidacy for Colorado's 8th congressional district in the 2022 elections.[2] She lost to Barbara Kirkmeyer in the Republican primary.[15]
In 2024, Saine ran for reelection to the Weld County Board of County Commissioners, but ran against fellow Republican Perry Buck for the at-large seat Buck held, rather than the District 3 seat Saine held.[16] Buck won the primary with over 63% of the vote.[17]
