Prauscello held a Junior Research Fellowship at the Scuola Normale Superiore, Pisa (from 2003 to 2004) followed by a Momigliano Fellowship in Arts at UCL from 2004 to 2006. In 2005, Prauscello was appointed as a University Lecturer, later Senior University Lecturer, at the University of Cambridge, and a Fellow and Director of Studies in Classics at Trinity Hall. From 2016 to 2018, she was a University Reader at the University of Cambridge, Faculty of Classics. In 2015, she held a Humboldt Fellowship at the Humboldt-Universität zu Berlin.[2] Since 2018, she has been a Senior Research Fellow at All Souls College, University of Oxford.[1][3]
Prauscello is on the editorial board of Sapienza Università Editrice, the Oxyrhynchus Papyri Management Committee, and since 2017 she is a co-editor of the Cambridge Classical Journal.[1] She is an editor, with Alessandro Barchiesi, Robert Fowler and Nigel Wilson, of the series Sozomena, which is published for the Herculaneum Society by Walter de Gruyter.