Luis Manzano

Manzano is the only child of Vilma Santos and Edu Manzano.^[3] His stepfather is Senator Ralph Recto, husband of his mother. Manzano has a maternal half-brother, Ryan Christian Recto, and three paternal half-siblings, Addie, Enzo and Diego Aspiras. His cousin is Andi Manzano, a former VJ for MTV Philippines, and also a radio DJ for Magic 89.9 FM.

Manzano studied at Colegio San Agustin - Makati for high school^[4] and at De La Salle–College of Saint Benilde in Malate, Manila, majoring in Hotel and Restaurant Institution Management.^[5]

Manzano started his career as an image model for clothing brand, 'Human'.^[6] He later pursued a television host and acting career. Manzano began his professional trajectory by working as a VJ for the renowned music channel, Myx, with Iya Villania.^[7] He later served as a host and performer on the television veriety show ASAP in 2003, and on the reality show Star Circle Quest in 2004.^[8] Following his hosting engagements, Manzano transitioned into acting, portraying the roles of Luigi in the sitcom series Bora and Pablo in the drama Kampanerang Kuba,^[9] both of which aired in 2005. In addition to his television work, Manzano was also part of the main cast in several films in consecutive years, including All About Love as Wesley (2006), Ang Cute ng Ina Mo! as Val Quizon (2007),^[10] In My Life as Mark Salvacion (2009),^[11] Hating Kapatid as Edzel (2010),^[12] and Petrang Kabayo as Erickson Santos (2010).^[13] Manzano starred in the comedy film Moron 5 and the Crying Lady in 2012 and its sequel in 2014,^[14] as well as in This Guy's in Love with U Mare! as Mike, also in 2012.^[15]

Manzano returned to hosting in 2007 through the talk show Entertainment Live,^[16] alongside Toni Gonzaga, Mariel Rodriguez, and Bianca Gonzalez. That same year, Manzano also co-hosted the reality game show Pinoy Big Brother: Teen Edition Plus with them.^[17] In 2010, he hosted the game show Panahon Ko 'To!: Ang Game Show ng Buhay Ko with Billy Crawford. He also co-hosted the reality talent competition Pilipinas Got Talent with Crawford from 2010 to 2016. In 2011, Manzano starred in the sketch comedy show Laugh Out Loud alongside Alodia Gosiengfiao.^[18] Manzano replaced Kris Aquino as host of the game show Kapamilya, Deal or No Deal from 2012 to 2016 and since 2026.^[19] In the same year, Manzano co-hosted the musical variety show Sarah G Live with Sarah Geronimo.^[20] He also hosted the game show Minute to Win It from 2013 to 2019.^[21]

From 2014 to 2015, Manzano served as host for both The Voice Kids^[22] and The Voice of the Philippines.^[23] Manzano replaced Billy Crawford as host of the game show Celebrity Playtime, which aired from 2015 to 2016.^[24] He then succeeded his father, Edu Manzano, as host of Family Feud from 2016 to 2017,^[25] before being replaced by Dingdong Dantes in 2022. Manzano was the original host of the talent competition The Voice Teens in 2017.^[26] In 2019, he hosted the interactive reality competition World of Dance Philippines alongside Pia Wurtzbach.^[27]

Manzano later replaced Billy Crawford as host of Season 3 of the singing and impersonation competition Your Face Sounds Familiar.^[28] He also headlined the variety show It's Your Lucky Day.^[29] As of 2024, Manzano serves as the host of the game show Rainbow Rumble. In October 2025, Manzano returned to hosting Pinoy Big Brother after seventeen years through Pinoy Big Brother: Celebrity Collab Edition 2.0.^[30]

Manzano ran for vice governor of Batangas in the 2025 local elections, but lost to outgoing governor Hermilando Mandanas.^[31] In December 2025, Manzano expressed he is no longer interested in pursuing a government position.^[32]

Manzano owns a taxi company, LBR Transport Inc.^[33] Manzano is also a member of Tau Gamma Phi, a fraternity established in the Philippines.^[34]

Before dating actress Jessy Mendiola in June 2016, he dated several other actresses including Nancy Castiglione, Anne Curtis, Jennylyn Mercado, and Angel Locsin. Manzano became engaged to Mendiola on December 12, 2020,^[35] and were married on February 21, 2021, in a civil wedding officiated by Lipa City Mayor Eric Africa at The Farm in San Benito (Barangay Tipakan Lipa, Batangas).^[36]

On August 11, 2022, the couple announced that they were expecting their first child. Their daughter, Isabella Rose Tawile "Peanut" Manzano was born on December 29, 2022.^[37]

Manzano and Mendiola's church wedding was officiated by Jesuit priest Carmelo Caluag II in a Coron, Palawan church and beach on February 15, 2024. Present were Edu Manzano, Vilma Santos, and the bride's parents Roger Tawile and Judith Mendiola, with their daughter Rosie as the "little bride."^[38][39]

In May 2024, Manzano was cleared of cancer after medical tests including biopsy of his head lump.^[40]