Simigliani began his career with Arroceros de Calabozo, featuring in the club's 4–1 Copa Venezuela loss to Atlético Venezuela in July 2016, at the age of seventeen.[2] He joined Atlético Socopó ahead of the club's first season in the Venezuelan Primera División, and on his debut, he scored the club's first goal in the competition; a 90th minute consolation in a 4–1 loss to Deportivo La Guaira.[3] Goals against Trujillanos[4] and Zulia[5] followed, drawing interest from clubs overseas. He went on trial with Chilean club Universidad de Chile in mid-2017, being initially assigned to the under-19 side.[6] Despite the trial set to last until the 2018, it was cut short due to Universidad de Chile having already hit their foreign player quota.[7]
On his return to Venezuela, Simigliani joined the academy of Deportivo Lara in March 2018. However, this spell was short-lived and in July of the same year, he joined Universidad Central de Venezuela (UCV).[8] The following season, he played for Deportivo JBL in the Venezuelan Segunda División, before ending 2019 with Ciudad Vinotinto.[9]
In August 2020 he moved to Spain, reportedly signing a two-year deal with Sant Jordi.[10] However, it was later revealed that he had not been registered, after his performances in training had failed to convince coaching staff.[11] He also encountered issues with his paperwork, and by the time he joined Naval Reinosa in 2021, he had spent seven months suspended.[12] Having helped Naval to the Regional Preferente de Cantabria title, with three goals in the five games he played in,[1] he joined Tercera RFEF club Inter Ibiza in July 2021.[13] He spent the 2022–23 season with As Pontes.
In 2023 he moved to Italy, signing with Finale 1908.[14][15] After fourteen goals for Finale, he joined Bianco Calcio,[1] where he continued his good goal-scoring form, winning the top scorer between the Eccellenza and Promozione leagues award, given by Gazzetta del Sud, having scored twenty-nine goals.[12][16] For the 2025–26 season, he joined ReggioRavagnese 1960 alongside his brother, Giancarlo, and scored nine goals in his first sixteen appearances for the club.[17]